AustralieFrV1, Main, Exploration, bibRecord, 005432

Common variants at 12q15 and 12q24 are associated with infant head circumference

Identifieur interne : 005432 ( Main/Exploration ); précédent : 005431; suivant : 005433

Common variants at 12q15 and 12q24 are associated with infant head circumference

Auteurs : H Rob Taal [Pays-Bas] ; Beate St Pourcain [Royaume-Uni] ; Elisabeth Thiering [Allemagne] ; Shikta Das [Royaume-Uni] ; Dennis O. Mook-Kanamori [Pays-Bas, Qatar] ; Nicole M. Warrington [Australie, Canada] ; Marika Kaakinen [Finlande] ; Eskil Kreiner-M Ller [Danemark] ; Jonathan P. Bradfield [États-Unis] ; Rachel M. Freathy [Royaume-Uni] ; Frank Geller [Danemark] ; M Nica Guxens [Espagne] ; Diana L. Cousminer [Finlande] ; Marjan Kerkhof [Pays-Bas] ; Nicholas J. Timpson [Royaume-Uni] ; M Arfan Ikram [Pays-Bas] ; Lawrence J. Beilin [Australie] ; Klaus B Nnelykke [Danemark] ; Jessica L. Buxton ; Pimphen Charoen [Royaume-Uni, Thaïlande] ; Bo Lund Krogsgaard Chawes [Danemark] ; Johan Eriksson [Finlande] ; David M. Evans [Royaume-Uni] ; Albert Hofman [Pays-Bas] ; John P. Kemp [Royaume-Uni] ; Cecilia E. Kim [États-Unis] ; Norman Klopp [Allemagne] ; Jari Lahti [Finlande] ; Stephen J. Lye [Canada] ; George Mcmahon [Royaume-Uni] ; Frank D. Mentch [États-Unis] ; Martina Müller [Allemagne] ; Paul F. O Eilly [Royaume-Uni] ; Inga Prokopenko [Royaume-Uni] ; Fernando Rivadeneira [Pays-Bas] ; Eric A P. Steegers [Pays-Bas] ; Jordi Sunyer [Espagne] ; Carla Tiesler [Allemagne] ; Hanieh Yaghootkar [Royaume-Uni] ; Monique M B. Breteler [Pays-Bas] ; Stephanie Debette [États-Unis] ; Myriam Fornage [États-Unis] ; Vilmundur Gudnason [Islande] ; Lenore J. Launer [États-Unis] ; Aad Van Der Lugt [Pays-Bas] ; Thomas H. Mosley [États-Unis] ; Sudha Seshadri [États-Unis] ; Albert V. Smith [Islande] ; Meike W. Vernooij [Pays-Bas] ; Alexandra If Blakemore ; Rosetta M. Chiavacci [États-Unis] ; Bjarke Feenstra [Danemark] ; Julio Fernandez-Benet [Royaume-Uni] ; Struan F A. Grant [États-Unis] ; Anna-Liisa Hartikainen [Finlande] ; Albert J. Van Der Heijden [Pays-Bas] ; Carmen I Iguez [Espagne] ; Mark Lathrop [France] ; Wendy L. Mcardle [Royaume-Uni] ; Anne M Lgaard [Danemark] ; John P. Newnham [Australie] ; Lyle J. Palmer [Canada] ; Aarno Palotie [Finlande, États-Unis, Royaume-Uni] ; Annneli Pouta [Finlande] ; Susan M. Ring [Royaume-Uni] ; Ulla Sovio [Royaume-Uni] ; Marie Standl [Allemagne] ; Andre G. Uitterlinden [Pays-Bas] ; H-Erich Wichmann [Allemagne] ; Nadja Hawwa Vissing [Danemark] ; Charles Decarli [États-Unis] ; Cornelia M. Van Duijn [Pays-Bas] ; Mark I. Mccarthy [Royaume-Uni] ; Gerard H. Koppelman [Pays-Bas] ; Xavier Estivill [Espagne] ; Andrew T. Hattersley [Royaume-Uni] ; Mads Melbye [Danemark] ; Hans Bisgaard [Danemark] ; Craig E. Pennell [Australie] ; Elisabeth Widen [Finlande] ; Hakon Hakonarson [États-Unis] ; George Davey Smith [Royaume-Uni] ; Joachim Heinrich [Allemagne] ; Marjo-Riitta Jarvelin [Finlande] ; Vincent W V. Jaddoe [Pays-Bas]

Source :

Nature genetics [ 1061-4036 ] ; 2012.

RBID : PMC:3773913

Descripteurs français

KwdFr :
- Chromosomes humains de la paire 12 (génétique), Complications de la grossesse (anatomopathologie), Complications de la grossesse (étiologie), Femelle, Grossesse, Humains, Locus génétiques, Marqueurs génétiques, Mâle, Méta-analyse comme sujet, Nourrisson, Polymorphisme de nucléotide simple (génétique), Population d'origine européenne (génétique), Tête (anatomopathologie), Tête (croissance et développement), Étude d'association pangénomique.
MESH :
- anatomopathologie : Complications de la grossesse, Tête.
- croissance et développement : Tête.
- génétique : Chromosomes humains de la paire 12, Polymorphisme de nucléotide simple, Population d'origine européenne.
- étiologie : Complications de la grossesse.
- Femelle, Grossesse, Humains, Locus génétiques, Marqueurs génétiques, Mâle, Méta-analyse comme sujet, Nourrisson, Étude d'association pangénomique.

English descriptors

KwdEn :
- Chromosomes, Human, Pair 12 (genetics), European Continental Ancestry Group (genetics), Female, Genetic Loci, Genetic Markers, Genome-Wide Association Study, Head (growth & development), Head (pathology), Humans, Infant, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide (genetics), Pregnancy, Pregnancy Complications (etiology), Pregnancy Complications (pathology).
MESH :
- chemical : Genetic Markers.
- etiology : Pregnancy Complications.
- genetics : Chromosomes, Human, Pair 12, European Continental Ancestry Group, Polymorphism, Single Nucleotide.
- growth & development : Head.
- pathology : Head, Pregnancy Complications.
- Female, Genetic Loci, Genome-Wide Association Study, Humans, Infant, Male, Meta-Analysis as Topic, Pregnancy.

Abstract

To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association (GWA) studies (N=10,768 from European ancestry enrolled in pregnancy/birth cohorts) and followed up three lead signals in six replication studies (combined N=19,089). Rs7980687 on chromosome 12q24 (P=8.1×10⁻⁹), and rs1042725 on chromosome 12q15 (P=2.8×10⁻¹⁰) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height¹, their effects on infant head circumference were largely independent of height (P=3.8×10⁻⁷ for rs7980687, P=1.3×10⁻⁷ for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P=3.9×10⁻⁶). SNPs correlated to the 17q21 signal show genome-wide association with adult intra cranial volume², Parkinson’s disease and other neurodegenerative diseases^3-5, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773913

DOI: 10.1038/ng.2238
PubMed: 22504419
PubMed Central: 3773913

Affiliations:

Allemagne, Australie, Canada, Danemark, Espagne, Finlande, France, Islande, Pays-Bas, Qatar, Royaume-Uni, Thaïlande, États-Unis
Angleterre, Basse-Saxe, Bavière, Californie, District de Haute-Bavière, Grand Londres, Groningue (province), Hollande-Méridionale, Hovedstaden, Maryland, Massachusetts, Ontario, Oxfordshire, Texas, Uusimaa, État du Mississippi, Île-de-France
Copenhague, Groningue, Hanovre, Helsinki, Londres, Munich, Oxford, Paris, Rotterdam, Toronto, Évry (Essonne)
Université d'Helsinki, Université d'Oxford, Université de Toronto

Le document en format XML

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<author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name>
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<author><name sortKey="Guxens, M Nica" sort="Guxens, M Nica" uniqKey="Guxens M" first="M Nica" last="Guxens">M Nica Guxens</name>
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<author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name>
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<author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
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<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
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<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<author><name sortKey="Beilin, Lawrence J" sort="Beilin, Lawrence J" uniqKey="Beilin L" first="Lawrence J" last="Beilin">Lawrence J. Beilin</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="B Nnelykke, Klaus" sort="B Nnelykke, Klaus" uniqKey="B Nnelykke K" first="Klaus" last="B Nnelykke">Klaus B Nnelykke</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
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<author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L" last="Buxton">Jessica L. Buxton</name>
<affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff>
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<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A24">Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chawes, Bo Lund Krogsgaard" sort="Chawes, Bo Lund Krogsgaard" uniqKey="Chawes B" first="Bo Lund Krogsgaard" last="Chawes">Bo Lund Krogsgaard Chawes</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
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<author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
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<affiliation wicri:level="4"><nlm:aff id="A26">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
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<affiliation wicri:level="4"><nlm:aff id="A27">Folkhalsan Research Centre, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Folkhalsan Research Centre, Biomedicum Helsinki, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P" last="Kemp">John P. Kemp</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Cecilia E" sort="Kim, Cecilia E" uniqKey="Kim C" first="Cecilia E" last="Kim">Cecilia E. Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A29">Hannover Unified Biobank, Hannover Medical School, Hannover, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hannover Unified Biobank, Hannover Medical School, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name>
<affiliation wicri:level="4"><nlm:aff id="A30">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lye, Stephen J" sort="Lye, Stephen J" uniqKey="Lye S" first="Stephen J" last="Lye">Stephen J. Lye</name>
<affiliation wicri:level="4"><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld Research Institute, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mentch, Frank D" sort="Mentch, Frank D" uniqKey="Mentch F" first="Frank D" last="Mentch">Frank D. Mentch</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Muller, Martina" sort="Muller, Martina" uniqKey="Muller M" first="Martina" last="Müller">Martina Müller</name>
<affiliation wicri:level="3"><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A32">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F" last="O Eilly">Paul F. O Eilly</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Department of Epidemiology and Biostatistics, Imperial College London, W2 1PG London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, W2 1PG London</wicri:regionArea>
<wicri:noRegion>W2 1PG London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<affiliation wicri:level="4"><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A P" last="Steegers">Eric A P. Steegers</name>
<affiliation wicri:level="3"><nlm:aff id="A38">Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Pompeu Fabra University (UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A40">Dr Von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr Von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yaghootkar, Hanieh" sort="Yaghootkar, Hanieh" uniqKey="Yaghootkar H" first="Hanieh" last="Yaghootkar">Hanieh Yaghootkar</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter</wicri:regionArea>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M B" last="Breteler">Monique M B. Breteler</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><nlm:aff id="A43">Institute of Molecular Medicine, Human Genetics Center and Division of Epidemiology, School of Public Health, University of Texas, Houston Health Sciences Center, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute of Molecular Medicine, Human Genetics Center and Division of Epidemiology, School of Public Health, University of Texas, Houston Health Sciences Center, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogus</wicri:regionArea>
<wicri:noRegion>Kopavogus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="2"><nlm:aff id="A46">Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="2"><nlm:aff id="A47">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogus</wicri:regionArea>
<wicri:noRegion>Kopavogus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W" last="Vernooij">Meike W. Vernooij</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blakemore, Alexandra If" sort="Blakemore, Alexandra If" uniqKey="Blakemore A" first="Alexandra If" last="Blakemore">Alexandra If Blakemore</name>
<affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chiavacci, Rosetta M" sort="Chiavacci, Rosetta M" uniqKey="Chiavacci R" first="Rosetta M" last="Chiavacci">Rosetta M. Chiavacci</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feenstra, Bjarke" sort="Feenstra, Bjarke" uniqKey="Feenstra B" first="Bjarke" last="Feenstra">Bjarke Feenstra</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fernandez Benet, Julio" sort="Fernandez Benet, Julio" uniqKey="Fernandez Benet J" first="Julio" last="Fernandez-Benet">Julio Fernandez-Benet</name>
<affiliation wicri:level="1"><nlm:aff id="A48">European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea>
<wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F A" last="Grant">Struan F A. Grant</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A50">Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104</wicri:regionArea>
<wicri:noRegion>Philadelphia PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name>
<affiliation wicri:level="1"><nlm:aff id="A51">Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Heijden, Albert J" sort="Van Der Heijden, Albert J" uniqKey="Van Der Heijden A" first="Albert J" last="Van Der Heijden">Albert J. Van Der Heijden</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="I Iguez, Carmen" sort="I Iguez, Carmen" uniqKey="I Iguez C" first="Carmen" last="I Iguez">Carmen I Iguez</name>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A52">Division of Environment and Health, Center for Public Health Research-CSISP, Valencia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Division of Environment and Health, Center for Public Health Research-CSISP, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation wicri:level="3"><nlm:aff id="A53">Centre National de Génotypage, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Génotypage, Evry</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A54">Foundation Jean Dausset, CEPH, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Foundation Jean Dausset, CEPH, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name>
<affiliation wicri:level="1"><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="M Lgaard, Anne" sort="M Lgaard, Anne" uniqKey="M Lgaard A" first="Anne" last="M Lgaard">Anne M Lgaard</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Newnham, John P" sort="Newnham, John P" uniqKey="Newnham J" first="John P" last="Newnham">John P. Newnham</name>
<affiliation wicri:level="1"><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name>
<affiliation wicri:level="4"><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld Research Institute, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A56">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation wicri:level="4"><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A57">Department of Medical Genetics, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Genetics, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A58">Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute of Harvard and MIT, Cambridge, MA 02142</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A59">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pouta, Annneli" sort="Pouta, Annneli" uniqKey="Pouta A" first="Annneli" last="Pouta">Annneli Pouta</name>
<affiliation wicri:level="1"><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M" last="Ring">Susan M. Ring</name>
<affiliation wicri:level="1"><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</wicri:regionArea>
<wicri:noRegion>Imperial College London</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A61">London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Standl, Marie" sort="Standl, Marie" uniqKey="Standl M" first="Marie" last="Standl">Marie Standl</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vissing, Nadja Hawwa" sort="Vissing, Nadja Hawwa" uniqKey="Vissing N" first="Nadja Hawwa" last="Vissing">Nadja Hawwa Vissing</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation wicri:level="2"><nlm:aff id="A62">Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name>
<affiliation wicri:level="4"><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A63">Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name>
<affiliation wicri:level="3"><nlm:aff id="A64">Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Estivill, Xavier" sort="Estivill, Xavier" uniqKey="Estivill X" first="Xavier" last="Estivill">Xavier Estivill</name>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Pompeu Fabra University (UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A65">Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name>
<affiliation wicri:level="1"><nlm:aff id="A66">Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter</wicri:regionArea>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name>
<affiliation wicri:level="1"><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name>
<affiliation wicri:level="4"><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name>
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<author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name>
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<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Health Sciences, University of Oulu</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff>
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<wicri:regionArea>National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu</wicri:regionArea>
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</affiliation>
<affiliation><nlm:aff id="A67">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London</nlm:aff>
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</author>
<author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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</placeName>
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<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common variants at 12q15 and 12q24 are associated with infant head circumference</title>
<author><name sortKey="Taal, H Rob" sort="Taal, H Rob" uniqKey="Taal H" first="H Rob" last="Taal">H Rob Taal</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
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</affiliation>
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<author><name sortKey="Pourcain, Beate St" sort="Pourcain, Beate St" uniqKey="Pourcain B" first="Beate St" last="Pourcain">Beate St Pourcain</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
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</author>
<author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
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<wicri:noRegion>Neuherberg</wicri:noRegion>
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</author>
<author><name sortKey="Das, Shikta" sort="Das, Shikta" uniqKey="Das S" first="Shikta" last="Das">Shikta Das</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</wicri:regionArea>
<wicri:noRegion>Imperial College London</wicri:noRegion>
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</author>
<author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<region nuts="2" type="province">Hollande-Méridionale</region>
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</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A7">Weill Cornell Medical College - Qatar, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Weill Cornell Medical College - Qatar, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
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<author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M" last="Warrington">Nicole M. Warrington</name>
<affiliation wicri:level="1"><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
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<affiliation wicri:level="4"><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld Research Institute, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Institute of Health Sciences, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Health Sciences, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11">Biocenter Oulu, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Biocenter Oulu, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kreiner M Ller, Eskil" sort="Kreiner M Ller, Eskil" uniqKey="Kreiner M Ller E" first="Eskil" last="Kreiner-M Ller">Eskil Kreiner-M Ller</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P" last="Bradfield">Jonathan P. Bradfield</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Freathy, Rachel M" sort="Freathy, Rachel M" uniqKey="Freathy R" first="Rachel M" last="Freathy">Rachel M. Freathy</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter</wicri:regionArea>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guxens, M Nica" sort="Guxens, M Nica" uniqKey="Guxens M" first="M Nica" last="Guxens">M Nica Guxens</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L" last="Cousminer">Diana L. Cousminer</name>
<affiliation wicri:level="4"><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beilin, Lawrence J" sort="Beilin, Lawrence J" uniqKey="Beilin L" first="Lawrence J" last="Beilin">Lawrence J. Beilin</name>
<affiliation wicri:level="1"><nlm:aff id="A22">School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine and Pharmacology, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="B Nnelykke, Klaus" sort="B Nnelykke, Klaus" uniqKey="B Nnelykke K" first="Klaus" last="B Nnelykke">Klaus B Nnelykke</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L" last="Buxton">Jessica L. Buxton</name>
<affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</wicri:regionArea>
<wicri:noRegion>Imperial College London</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A24">Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chawes, Bo Lund Krogsgaard" sort="Chawes, Bo Lund Krogsgaard" uniqKey="Chawes B" first="Bo Lund Krogsgaard" last="Chawes">Bo Lund Krogsgaard Chawes</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
<affiliation wicri:level="1"><nlm:aff id="A25">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A26">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A27">Folkhalsan Research Centre, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Folkhalsan Research Centre, Biomedicum Helsinki, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P" last="Kemp">John P. Kemp</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Cecilia E" sort="Kim, Cecilia E" uniqKey="Kim C" first="Cecilia E" last="Kim">Cecilia E. Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A29">Hannover Unified Biobank, Hannover Medical School, Hannover, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hannover Unified Biobank, Hannover Medical School, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name>
<affiliation wicri:level="4"><nlm:aff id="A30">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lye, Stephen J" sort="Lye, Stephen J" uniqKey="Lye S" first="Stephen J" last="Lye">Stephen J. Lye</name>
<affiliation wicri:level="4"><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld Research Institute, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mentch, Frank D" sort="Mentch, Frank D" uniqKey="Mentch F" first="Frank D" last="Mentch">Frank D. Mentch</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Muller, Martina" sort="Muller, Martina" uniqKey="Muller M" first="Martina" last="Müller">Martina Müller</name>
<affiliation wicri:level="3"><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A32">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F" last="O Eilly">Paul F. O Eilly</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Department of Epidemiology and Biostatistics, Imperial College London, W2 1PG London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, W2 1PG London</wicri:regionArea>
<wicri:noRegion>W2 1PG London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<affiliation wicri:level="4"><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A P" last="Steegers">Eric A P. Steegers</name>
<affiliation wicri:level="3"><nlm:aff id="A38">Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Pompeu Fabra University (UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A40">Dr Von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr Von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yaghootkar, Hanieh" sort="Yaghootkar, Hanieh" uniqKey="Yaghootkar H" first="Hanieh" last="Yaghootkar">Hanieh Yaghootkar</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter</wicri:regionArea>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M B" last="Breteler">Monique M B. Breteler</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><nlm:aff id="A43">Institute of Molecular Medicine, Human Genetics Center and Division of Epidemiology, School of Public Health, University of Texas, Houston Health Sciences Center, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute of Molecular Medicine, Human Genetics Center and Division of Epidemiology, School of Public Health, University of Texas, Houston Health Sciences Center, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogus</wicri:regionArea>
<wicri:noRegion>Kopavogus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="2"><nlm:aff id="A46">Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="2"><nlm:aff id="A47">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogus</wicri:regionArea>
<wicri:noRegion>Kopavogus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W" last="Vernooij">Meike W. Vernooij</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blakemore, Alexandra If" sort="Blakemore, Alexandra If" uniqKey="Blakemore A" first="Alexandra If" last="Blakemore">Alexandra If Blakemore</name>
<affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chiavacci, Rosetta M" sort="Chiavacci, Rosetta M" uniqKey="Chiavacci R" first="Rosetta M" last="Chiavacci">Rosetta M. Chiavacci</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feenstra, Bjarke" sort="Feenstra, Bjarke" uniqKey="Feenstra B" first="Bjarke" last="Feenstra">Bjarke Feenstra</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fernandez Benet, Julio" sort="Fernandez Benet, Julio" uniqKey="Fernandez Benet J" first="Julio" last="Fernandez-Benet">Julio Fernandez-Benet</name>
<affiliation wicri:level="1"><nlm:aff id="A48">European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea>
<wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F A" last="Grant">Struan F A. Grant</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A50">Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104</wicri:regionArea>
<wicri:noRegion>Philadelphia PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name>
<affiliation wicri:level="1"><nlm:aff id="A51">Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Heijden, Albert J" sort="Van Der Heijden, Albert J" uniqKey="Van Der Heijden A" first="Albert J" last="Van Der Heijden">Albert J. Van Der Heijden</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="I Iguez, Carmen" sort="I Iguez, Carmen" uniqKey="I Iguez C" first="Carmen" last="I Iguez">Carmen I Iguez</name>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A52">Division of Environment and Health, Center for Public Health Research-CSISP, Valencia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Division of Environment and Health, Center for Public Health Research-CSISP, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation wicri:level="3"><nlm:aff id="A53">Centre National de Génotypage, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Génotypage, Evry</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A54">Foundation Jean Dausset, CEPH, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Foundation Jean Dausset, CEPH, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name>
<affiliation wicri:level="1"><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="M Lgaard, Anne" sort="M Lgaard, Anne" uniqKey="M Lgaard A" first="Anne" last="M Lgaard">Anne M Lgaard</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Newnham, John P" sort="Newnham, John P" uniqKey="Newnham J" first="John P" last="Newnham">John P. Newnham</name>
<affiliation wicri:level="1"><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name>
<affiliation wicri:level="4"><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld Research Institute, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A56">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation wicri:level="4"><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A57">Department of Medical Genetics, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Genetics, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A58">Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute of Harvard and MIT, Cambridge, MA 02142</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A59">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pouta, Annneli" sort="Pouta, Annneli" uniqKey="Pouta A" first="Annneli" last="Pouta">Annneli Pouta</name>
<affiliation wicri:level="1"><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M" last="Ring">Susan M. Ring</name>
<affiliation wicri:level="1"><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</wicri:regionArea>
<wicri:noRegion>Imperial College London</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A61">London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Standl, Marie" sort="Standl, Marie" uniqKey="Standl M" first="Marie" last="Standl">Marie Standl</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vissing, Nadja Hawwa" sort="Vissing, Nadja Hawwa" uniqKey="Vissing N" first="Nadja Hawwa" last="Vissing">Nadja Hawwa Vissing</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation wicri:level="2"><nlm:aff id="A62">Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name>
<affiliation wicri:level="4"><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A63">Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name>
<affiliation wicri:level="3"><nlm:aff id="A64">Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Estivill, Xavier" sort="Estivill, Xavier" uniqKey="Estivill X" first="Xavier" last="Estivill">Xavier Estivill</name>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Pompeu Fabra University (UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A65">Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name>
<affiliation wicri:level="1"><nlm:aff id="A66">Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter</wicri:regionArea>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name>
<affiliation wicri:level="1"><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name>
<affiliation wicri:level="4"><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A50">Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104</wicri:regionArea>
<wicri:noRegion>Philadelphia PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Institute of Health Sciences, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Health Sciences, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="A67">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature genetics</title>
<idno type="ISSN">1061-4036</idno>
<idno type="eISSN">1546-1718</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosomes, Human, Pair 12 (genetics)</term>
<term>European Continental Ancestry Group (genetics)</term>
<term>Female</term>
<term>Genetic Loci</term>
<term>Genetic Markers</term>
<term>Genome-Wide Association Study</term>
<term>Head (growth & development)</term>
<term>Head (pathology)</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Meta-Analysis as Topic</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Pregnancy</term>
<term>Pregnancy Complications (etiology)</term>
<term>Pregnancy Complications (pathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Chromosomes humains de la paire 12 (génétique)</term>
<term>Complications de la grossesse (anatomopathologie)</term>
<term>Complications de la grossesse (étiologie)</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Locus génétiques</term>
<term>Marqueurs génétiques</term>
<term>Mâle</term>
<term>Méta-analyse comme sujet</term>
<term>Nourrisson</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Population d'origine européenne (génétique)</term>
<term>Tête (anatomopathologie)</term>
<term>Tête (croissance et développement)</term>
<term>Étude d'association pangénomique</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Genetic Markers</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Complications de la grossesse</term>
<term>Tête</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Tête</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pregnancy Complications</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 12</term>
<term>European Continental Ancestry Group</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Head</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromosomes humains de la paire 12</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Population d'origine européenne</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Head</term>
<term>Pregnancy Complications</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Complications de la grossesse</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Genetic Loci</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Meta-Analysis as Topic</term>
<term>Pregnancy</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Locus génétiques</term>
<term>Marqueurs génétiques</term>
<term>Mâle</term>
<term>Méta-analyse comme sujet</term>
<term>Nourrisson</term>
<term>Étude d'association pangénomique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P7">To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association (GWA) studies (N=10,768 from European ancestry enrolled in pregnancy/birth cohorts) and followed up three lead signals in six replication studies (combined N=19,089). Rs7980687 on chromosome 12q24 (<italic>P</italic>
=8.1×10<sup>−9</sup>
), and rs1042725 on chromosome 12q15 (<italic>P</italic>
=2.8×10<sup>−10</sup>
) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height<sup><xref ref-type="bibr" rid="R1">1</xref>
</sup>
, their effects on infant head circumference were largely independent of height (<italic>P</italic>
=3.8×10<sup>−7</sup>
 for rs7980687, <italic>P</italic>
=1.3×10<sup>−7</sup>
 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (<italic>P</italic>
=3.9×10<sup>−6</sup>
). SNPs correlated to the 17q21 signal show genome-wide association with adult intra cranial volume<sup><xref ref-type="bibr" rid="R2">2</xref>
</sup>
, Parkinson’s disease and other neurodegenerative diseases<sup><xref ref-type="bibr" rid="R3">3</xref>
-<xref ref-type="bibr" rid="R5">5</xref>
</sup>
, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.</p>
</div>
</front>
</TEI>
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<li>Australie</li>
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<li>États-Unis</li>
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<li>Paris</li>
<li>Rotterdam</li>
<li>Toronto</li>
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</settlement>
<orgName><li>Université d'Helsinki</li>
<li>Université d'Oxford</li>
<li>Université de Toronto</li>
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<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
<name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name>
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<name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name>
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<name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name>
<name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name>
<name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name>
<name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name>
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<name sortKey="Taal, H Rob" sort="Taal, H Rob" uniqKey="Taal H" first="H Rob" last="Taal">H Rob Taal</name>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name>
<name sortKey="Van Der Heijden, Albert J" sort="Van Der Heijden, Albert J" uniqKey="Van Der Heijden A" first="Albert J" last="Van Der Heijden">Albert J. Van Der Heijden</name>
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<name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name>
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<name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name>
<name sortKey="Muller, Martina" sort="Muller, Martina" uniqKey="Muller M" first="Martina" last="Müller">Martina Müller</name>
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</country>
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   |texte=   Common variants at 12q15 and 12q24 are associated with infant head circumference
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Serveur d'exploration sur les relations entre la France et l'Australie

Common variants at 12q15 and 12q24 are associated with infant head circumference

Common variants at 12q15 and 12q24 are associated with infant head circumference

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	Serveur d'exploration sur les relations entre la France et l'Australie
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